After attending school in Chernigov, Semenyuk enrolled at the Architecture Department of Kyiv Institute of Engineering and Construction in 1935. Her study was interrupted by the Second World War, during which she worked at evacuated construction organizations in Biysk (Altay region, Russia). In 1944, she returned to Kyiv to continue her studies, graduating in 1947. Semenyuk worked at the Kyiv Institute of Construction and Design Oblprojekt, where she became chief project architect and eventually head of an architecture workshop. 

Among Semenyuk’s projects are: Palace of Culture in Svenyhorodka (1948), cinema in Chernigov and in Nizhyn (1949-1950), interior design of the library of the Central Committee of the Communist Party of Ukraine in Kyiv (1953 with Tamara Eligulashvili), development of the central square in Pereyaslav-Khmelnytskyi (1954 with Olga Lozinska, Tamara Eligulashvili), reconstruction of residential buildings in Kyiv (1956, 1960), reconstruction of the main building of the Ukrainian Academy of Agriculture in Kyiv (1959), Universytet station of the first line of the Kyiv Metro (1960 with with Olga Lozinska, Tamara Eligulashvili), experimental model village Kodaki, Kyiv region (1960-1970s), medical center and the Therapeutic and Surgical Building of the Regional Hospital in Kyiv (1974-1975 with Tamara Eligulashvili), construction of the Central Square in Vyshhorod (1979), Restoration of the Oleksandriya Dendrological Park in Bila Tserkva (1980).

Semenyuk was a recipient of several awards, including the Medal of Honor of the Soviet Union (1961), and the Prize of the Council of Ministers of the USSR (1971) for the construction of the Experimental Model Village Kodaki.