Born in Smolensk, Russia, in 1900, before 1909 Manucharova moved to Kyiv, where she finished high school in 1917, proceeding to work as a draftswoman at the construction of the Moscow-Kiev-Voronezh railway in Surazh, Chernihiv Oblast (now Bryansk Oblast, Russia). Between 1919 and 1921 she studied at Kyiv University, and between 1921 and 1924 at the Department of Architecture of Kyiv Art Institute, from which she graduated in 1930. While studying, between 1927 and 1930 she worked as a technician on the construction of the Kyiv railway station. 

Upon graduation, she moved to Kharkiv, where she was employed as an architect at the NKVD (The People’s Commissariat for Internal Affairs) Design Office, later reorganized as Dimpomiso (State Institute of Urban Design), between 1930 and 1934. During this time, she designed several pavilions of the Dynamo Stadium in Kharkiv (1931). In 1934, she was appointed the chief architect of the Dynamo Stadium in Kyiv, remaining in this position until 1936. 

Having moved to Kyiv, she was later employed in Shkilproekt (1936-1938), Transproekt (1938-1939), Golovvoenbud (1940), and Tsivilproekt (1940-1941). During the Second World War she was evacuated to Zlatoust (1941-1943) and Kyibushev (contemporary Samara, 1943) in Russia, where she continued working. Upon returning to Ukraine in the wake of the retreat of the German army, she was employed as an architect of the People’s Commissariat of State Farms (1943-1944) and headed the Section of Architecture under the Council of Ministers of the Ukrainian SSR in Kyiv (1944-1946). In 1946 she was elected a corresponding member of the Academy of Architecture of the Ukrainian Socialist Federative Republic within the section of industrial design.

In 1951, Manucharova received her doctorate, after which she dedicated herself to research. She became a deputy director for research at the Research Institute of Art Industry of the Academy of Architecture of the Ukrainian republic (1956-1957), the head of the section of interior design of the Research Institute of Architecture of Buildings of the Academy of Architecture and Construction of the Ukrainian republic (1957-1964), and a senior researcher at KyivZNDIEP (Ukrainian Zonal Scientific-Research and Design Institute of Civil Construction) between 1964 and her retirement in 1970.

Manucharova supervised and edited a number of publications including such volumes as Decorative Fabrics (1949), Domestic Furniture (1951), Ukrainian Folk Decorative Art (book series, 1952— 1953), Architectural Ceramics (1951), Hutsul Ceramics (1954), Furniture for Living (1955).

Manucharova’s husband was a metal recycling manager. One of their two daughters, Alexandra Pavlovskaya (Yakutovich) became a children’s book illustrator.