Ladyhina was born in Moscow in 1922 in the family of road engineer Boris Ladyhin. In 1926, the family moved to Minsk, Belarus, her mother’s native city. Her maternal aunt, Larysa Aleksandrouskaya, was a renowned Belarusian opera singer. In 1938, the family moved to Saratov, Russia, to avoid intensifying Stalinist repressions. In the 1950s, Boris Ladyhin would return to Belarus to build a highly successful academic career (he would become a professor and a corresponding member of Belarus Academy of Sciences).

In 1940, Ladyhina became a student at the Department of Architecture of Leningrad Institute of Engineering and Construction. In September 1941, the city was besieged by the German army. Ladyhina participated in building fortifications until she was evacuated from Leningrad in March of 1942. She moved to her parents in Saratov, where she worked while also studying at Saratov Institute of Road Construction (where her father was teaching). In 1944, Ladyhina was able to transfer to Moscow Institute of Architecture, from which she graduated in 1949. In Moscow, she married her fellow-student Evgeny Zaslavsky (Yaugen Zaslausky), who would become a leading Belarusian architect and a professor at Belarusian Polytechnic Institute. Upon graduation, the couple moved to Minsk, heavily destroyed by the Second World War.

In Minsk, Ladyhina started working at Beldzyarzhpraekt institute, where she would remain for her entire professional career, moving from a regular architect to the head architect of the institute. Over eighty of the projects that she designed for the city were realized. Working under the former Constructivist Mikhail Barshch during the 1950s, Ladyhina designed the main building of Belarusian Institute of Technology (1956-1958), residential buildings on Ya. Kupala street, and on the Victory square (among others). Her independent projects of this time include bridges over Zapadnaya Dvina in Vitebsk (1955) and over Dnepr in Mogilev.

During the 1960s, she designed medical centers, including the Republican Institute of Oncology and Medical Radiology in Baraulyany (1963) and the Republican Hospital in Lyasnoe village near Minsk (1967), residential buildings in Chilanzar microdistrict of Tashkent (following destruction caused by the earthquake of 1966), the Palace of Water Sports in Minsk (1967), and the Khimvolokno factory palace of culture in Mogilev (1977). In Minsk, she also designed the masterplan and buildings for V. Kharuzhay, M. Gorky, Kh. Kulman, and other streets (1954-1987).

Ladyhina was the chairwoman of the Board of the Union of Architects of Belorussian Soviet Socialist Republic in 1961-1964. She was awarded the title of distinguished architect of Belarussian Soviet Socialist Republic in 1969 (becoming one of its first recipients), among multiple other awards. She participated in the congresses of the International Union of Architects in Havana (1963) and in Madrid (1975), as well as in the International Congress of Women in Moscow (1963).