Born near Zhitomir, in 1954, Moiseenko graduated from the Architecture Department of Kyiv Institute of Engineering and Construction, where she studied under modernist architect Joseph Karakis. Between 1954 and 1977, she worked at several design institutes, focusing on rural architecture in Ukraine and Moldova and on the history of Ukrainian and Moldovan architecture. In 1962, Moiseenko defended a Ph.D. dissertation on rural architecture in Moldova at the Academy of Architecture of the USSR. Between 1963 and 1971, she worked at Ukranian Zonal Research and Design Institute for Civil Construction (KyivZNDIEP). Between 1965 and 1990, Moiseenko was a deputy head of the Union of Architects of Ukraine; between 1985 and 1990 she was also a board member at the Union of Soviet Architects. Between 1982 and 1990 she was a jury member for State and Lenin prizes in literature, art, and architecture. 

Among her design projects are residential buildings in Kyiv (1955-1957) and a series of typified rural houses for Ukraine. She also authored multiple academic publications, including books on rural architecture in Moldova and Ukraine, modern architecture, Ukrainian architecture and architects, including V. Zabolotnyi, J. Samoylovych, and O. Tatsyi. 

Moiseenko received her secondary doctorate degree in 1981. In 1990, she was appointed Professor of Theory and History of Architecture and the Synthesis of the Arts at Kyiv Art Institute. She was also selected as a member of the Academy of Architecture of Ukraine.

Moiseenko was married to Viktor Chepelyk, professor at Kyiv Institute of Engineering and Construction. Their daughter Oksana became an architect and artist.